Education
- 2009
Bachelor degree from Clinical PharmacyPharmacy College, King Abdulaziz University, جدة, المملكة العربية السعودية
- 2014
Master degree from PharmaceuticsPharmacy, Massachusetts College of Pharmacy and Health Sciences University, بوسطن, امــريــكـا
- 2019
Doctorate degree from PharmaceuticsUCL School of Pharmacy, University College London, لندن, بريطانيا
Employment
- 2010-2012
Dominstrator, King Abdulaziz University, جدة, المملكة العربية السعودية
- 2015-2017
Admin of Medicinal Chemistry Lab & Biotechnology Lab, UCL School of Pharmacy, لندن, بريطانيا
- 2015-2018
Senior Researcher, Nanomerics Ltd, لندن, بريطانيا
- 2019-حاليا
Assistant Professor of Pharmaceutical Nanoscience, King Abdulaziz University, جدة, المملكة العربية السعودية
Research Interests
Drug Delivery Systems and Nanoparticulates Formulation
Scientific interests
Designing and Synthesis Polymeric Nanoparticles for Gene and Drug Delivery, Nanoparticles Drug Loading, Characterising Pharmaceutical Formulations, Advanced Analytical Techniques, Stability Studies, Drug Targeting, In Vitro and In Vivo Studies
Areas of expertise
| Oral Gene Dilevery |
Oral gene delivery of non-viral vectors is the most attractive strategy due to ease of administration, leading to improved patients convenience, and reducing the overall healthcare cost. However, the oral delivery of nucleic acid is the greatest challenge facing the drug delivery industry. The harsh condition in the gastrointestinal tract (GIT) would destabilise the formulation and hence minimise the therapeutic effect The membrane-bound brush-border enzymes and the pancreatic enzymes that are secreted in the intestine may also cause a substantial loss of nucleic acid activity. Thus, formulating the gene into nanoparticles is one proposed method to overcome these enzymatic and physical barriers. Cationic polymers can improve the pharmacokinetics, pharmacodynamics, biodistribution and toxicology of nucleic acids due to their ability to bind and condense the nucleic acids into stabilised nanoparticles |